It is recommended to take it out in one hit, or knock it down to about 1/4 of its max HP and then try to kill it in one go to avoid its explosion attacks, though having Fire-resistant equipment or abilities will help nullify that. In Oversoul, it is best to take it out as fast as possible. Using Black Sky, Flare, Ultima, or high-powered physical attacks works well against it.
Fiend Tale Edit
In the Fiend Tale endings, a notable Volcano escaped the capture of his kin by members of the Order of Yevon who intended to develop weapons from them. With the Gullwings' help, Volcano reaches Bevelle's underground where the experiments took place and uses his Self-Destruct to kill the Yevon scientists.