The Save the Queen is a greatsword in Final Fantasy XII. Its license costs 70 LP. In the Zodiac versions, it can be equipped by Knight, White Mage and Red Battlemage. The White Mage needs to unlock Chaos on the License Board to reach it (or in The Zodiac Age, duo with a job that gets the +310 HP license), and the Red Battlemage needs to unlock Ultima.
Save the Queen is a weapon.
"Save the Queen" is likely derived from God Save the Queen, the anthem used in a number of Commonwealth realms, their territories, and the British Crown Dependencies.