Confrontation is a status ailment in Final Fantasy XI that forces a confrontation between a character or character party and a specific monster or monster group. It does this by preventing the player from receiving external aid, or from attacking or affecting monsters other than the specially designated monsters—such actions simply are not allowed to occur. Also, when Confrontation is inflicted, the affected players will have their Pets dismissed.
Confrontation status is gained by initiating certain optional battles—it isn't something that monsters can just randomly inflict. Confrontation cannot be removed by any means other than completing the battle, whether by victory or by defeat.