There's two main antagonists, Seymour and Jecht. Just like there's two protagonists, Yuna and Tidus.
Since there's two different protagonists, each has their own antagonist as well: Jecht for Tidus and Seymour for Yuna.
Yu Yevon, and the religion born from it, is the main villain, not antagonist. I have no idea how many times I've said this.
This question has been asked before Shuyin knows how many times, I myself having asking it following by a post explaining my position (aka what I just said) long time ago. Also, it's not exactly a pop quiz if there's no 100% correct answer, or am I the only one who thinks that? Welp, guess I can't vote.
That's what makes FFX so great and distinguishable.